Type
Text
Type
Thesis
Advisor
Drueckhammer, Dale G. | Rudick, Jonathan | Parker, Kathlyn.
Date
2015-08-01
Keywords
Chemistry
Department
Department of Chemistry.
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/77126
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
Nucleic acid mimics and analogs are artificially designed molecular strands that can bind to natural nucleic acids. They have far-reaching diagnostics and therapeutics applications. An ideal nucleic acid mimic should exhibit strong binding affinity to complementary DNA or RNA and excellent resistance to nucleases. Numerous nucleic acid mimics such as PNA, LNA and morpholino oligonucleotides have been studied for decades. In our study, we aim to synthesize novel improved nucleic acid analogs. We have designed various nucleic acid mimics by computational methods. An analog was chosen for synthesis consisting of a piperidine backbone and a " sandwich" base that intercalates adjacent base pairs. This thesis describes the development of synthetic routes to the " sandwich" base and exploration of a route to the piperidine backbone. | 63 pages
Recommended Citation
Liu, Xiao, "Synthesis of a Novel Sandwich Base Nucleic Acid Analog" (2015). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 2962.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/2962