Type
Text
Type
Thesis
Advisor
London, Erwin. | Seeliger, Jessica | Tonge, Peter
Date
2013-12-01
Keywords
Chemistry
Department
Department of Chemistry.
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/77086
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
Two lipoproteins, MtbLprG and MtbLprA, have been characterized as TLR2 agonists. Knockout of the lprG operon (lprG-rv1410c) results in decreased virulence of M. tb. While their importance for host-pathogen interactions has been the subject of numerous studies, the physiological functions of LprG and LprA are not known. We present here data towards elucidating the physiological functions of LprG and LprA, both in M. tb and M. smegmatis, including localization, binding affinity to respective ligands, as well as the phenotype of knockout strains, which will contribute a model for lipid transport through the cell wall. | 46 pages
Recommended Citation
Bai, Lu, "Characterizing the lipoproteins LprG and LprA towards a better understanding of lipid transport mechanisms in Mycobacterium tuberculosis" (2013). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 2923.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/2923