Type
Text
Type
Thesis
Advisor
Tannenbaum, Irena | Venkatesh, T. | Abdelaziz, Sherif.
Date
2016-12-01
Keywords
Materials Science | biodegradable polymer, Bone scaffold, degradation
Department
Department of Materials Science and Engineering.
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/76342
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
Bone tissue engineering is a rapidly developing field of interest. Bone scaffold materials have several applications of great importance including the fostering of healthy bone tissue and the repair of bone defects both in-vivo and in-vitro. Ideal scaffolds should be biocompatible, biodegradable, and promote cellular interactions and tissue development, and possess proper mechanical and physical properties. nHAP-PLGA-Collagen is a novel synthesized block-polymer which has proved biocompatibility and mechanical properties. This thesis is focused on the degradation-controlling to fulfill the requirement of bone reconstruction and afterward digestion. The research focuses on internal and external factors which have effects on degradation time of nHAP-PLGA-Collagen. Internal factors include monomer ratio of D, L-lactide and glycolide monomers, porosity, and macro construction, which can modify the polymer. And external factors are temperature and pH impact the degradation of storage and during bone forming. In this thesis, nHAP-PLGA-Collagen block polymer has been characterized and been proven to have properties accounting for a bone scaffold material, including degradation adaptability. | 54 pages
Recommended Citation
Ren, Liqiang, "Basic Study on Degradation of nHAP-PLGA-Collagen – A Novel Biopolymer | Basic Study on Degradation of nHAP-PLGA-Collagen – A Novel Biopolymer" (2016). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 2266.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/2266