Type
Text
Type
Thesis
Advisor
Bogenhagen, Daniel , Garcia-Diaz, Miguel
Date
2012-12-01
Keywords
Molecular biology--Cellular biology--Biochemistry | Apoptosis, BH3-like Domain, FASTKD4, FAST Kinase, Mitochondria, TBRG4
Department
Department of Biochemistry and Cell Biology
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/71040
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
Mitochondria play an essential role in eukaryotic cells, supplying energy levels which vastly exceed those available to prokaryotes. They rely heavily on the import of nuclear encoded proteins for their function. The FAST family of proteins which are synthesized in the cytoplasm and imported into mitochondria are an example of this. The FAST family has not been well characterized, and next to nothing is known about several FAST family members. In the following I have reviewed what is known about each member of the FAST protein family including conserved domains, structures, including roles in cellular function, apoptosis and disease. Additionally, our lab has begun to characterize FASTKD4, one of the least studied FAST family members. We have determined that FASTKD4 is both a cytoplasmic and a mitochondrial protein, it does not reside in the outer mitochondrial membrane, its overexpression is not acutely toxic, and preliminary results suggest that it is not a member of any large complex in resting cells. | 65 pages
Recommended Citation
St Clair, Johnna, "Fas-Activated Serine Threonine Kinase 4 is a Mitochondrial Protein" (2012). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 247.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/247