Type
Text
Type
Thesis
Advisor
Tadanori Koga | Finch, Stephen J. | Milutin Stanacevic.
Date
2010-05-01
Keywords
bone, composites, hydroxyapatite, tissue engineering | Engineering, Materials Science
Department
Department of Materials Science and Engineering
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/72712
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
Natural bone is composed of natural polymers, collagen fibers and nano-crystals of minerals, mainly nano-hydroxyapatite (HA). Bone cells, which maintain the activities and metabolism of bone, are supported by and interact with this organic-inorganic hybrid matrix. Artificial bone tissue scaffolds mimicking the natural bone's extracellular matrix based on synthetic hybrid cellulose acetate (CA)-hydroxyapatite nano-composites were fabricated in this work in 3D matrix architecture for bone cell regeneration, using a single step nano-manufacturing technique. Cultured human osteoblasts were seeded on CA and CA-HA scaffolds, after which cell proliferative capacity and viability were studied using complementary assays. The interactions between the cells and the scaffolds were further characterized by scanning electron microscopy (SEM). Osteoblasts grown on these scaffolds appear to interact strongly with nano-HA clusters, resulting in cell growth and phenotype retention. The hybrids scaffolds used are shown to be ideal bone repair agents.
Recommended Citation
Xue, Ruipeng, "Hybrid Nanostructures for Bone Tissue Engineering" (2010). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 1915.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/1915