Type
Text
Type
Thesis
Advisor
Reich, Nancy. | Carpino, Nick
Date
2011-12-01
Keywords
Immunology--Biochemistry | CD4+CD25+, Foxp3, Regulatory T cells, Sts-1, Sts-2, Treg
Department
Department of Biochemistry and Cell Biology
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/71413
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
Regulatory T cells (Tregs) play a critical role in down-regulating immune responses to self antigens. Here we assess the significance of Sts-1 and Sts-2, two protein phosphatases that negatively regulate TCR signaling, in the development and maintenance of Tregs. We show that the number of splenic Tregs in vivo is elevated in the absence of Sts-1and Sts-2. We also found that Sts-1 and Sts-2 play a redundant role in TGF--mediated induction of Tregs in vitro. These data indicate that the Sts proteins are crucial for the maintenance of normal Treg populations in mice and also in TGF--mediated induction of Tregs in vitro. | 30 pages
Recommended Citation
Sivaram, Nithya, "An initial analysis of the role of Sts-1 and Sts-2 in the development of regulatory T cells" (2011). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 619.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/619