Type

Text

Type

Thesis

Advisor

Drueckhammer, Dale G. | Ojima, Iwao. | Goroff, Dancy S.

Date

2017-08-01

Keywords

Chemistry, Organic | Cytology

Department

Department of Chemistry.

Language

en_US

Source

This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree

Identifier

http://hdl.handle.net/11401/78349

Publisher

The Graduate School, Stony Brook University: Stony Brook, NY.

Format

application/pdf

Abstract

Despite recent advances in the detection and treatment of cancer, it remains the second most common cause of death in the United States, second only to heart disease. It is estimated that half of all men and a third of all women in America will develop cancer in their lifetimes. Traditional chemotherapy is predicated on the idea that rapidly dividing cells (such as tumor cells in nascent stages of cancer development), can be targeted preferentially by chemotherapeutic agents. Commonly, plant alkaloids, such as vincristine and paclitaxel, have been utilized to induce apoptosis in cancer cells. Next generation taxoid SB-T-1214, a taxoid superior to paclitaxel, was synthesized. Molecular dynamics simulations of the further improved third generation taxoids SB-T-1214-05 and SB-T-1214-06 were performed to investigate the discrepancy in their potencies against certain cancer cell lines. Another natural product, Combretastatin A-4 (CA4) is known to act as a vascular disrupting agent (VDA) by increasing the permeability of tumor vasculature, causing leakage of plasma proteins and reduction of vessel diameter. The reduction in diameter causes high interstitial fluid pressure and results in red blood cell stacking, increasing the viscosity of the blood and effectively choking the tumor of nutrients, resulting in tumor necrosis. In this research, novel fluorine-containing CA4 analogs were designed following virtual screening using DOCK 6.7 and use of docking software with Glide and Autodock Vina. The analogs were synthesized for evaluation against different cancer cell lines. | 121 pages

Download

Share

COinS