Type
Text
Type
Dissertation
Advisor
Yin, Wei | Frame, Mary D. | Rubenstein, David | Pittman, Roland.
Date
2016-12-01
Keywords
Aggregation, Erythrocyte, Microcirculation, Microfluidics, nanobubble, oxygen | Biomedical engineering
Department
Department of Biomedical Engineering.
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/76998
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
Red Blood Cell (RBC) aggregation is an important hemorheological phenomenon especially in microcirculation. In healthy individuals, RBCs are known to aggregate and gravitate toward the faster flow in the center of vessels to increase their throughput for more efficient oxygen delivery. Their aggregation is known to occur during a variety of environmental, pathological, and physiological conditions and is reversible when aggregates are subject to the relatively high shear forces in the circulation. The likelihood that aggregates will monodisperse in flow is dependent on the conditions during which they form. In situations where such aggregates are not sheared to monodispersion their presence can impact the perfusion of microvascular networks. More specifically, aggregates subject to the low shear rates in the zone of stasis near regions of thermal burn injury are capable of occluding vessels in the microcirculation and inhibiting the delivery of oxygen and nutrients to tissue downstream. The basic mechanism leading to erythrocyte aggregation at the onset of thermal injury is unknown. This dissertation investigates parameters involved in erythrocyte aggregation, methods of measuring and testing erythrocyte aggregation, and incorporates modeling based on first principles ultimately to propose a mechanism of this phenomenon. | 190 pages
Recommended Citation
Seidner, Harrison Steven, "Erythrocyte Aggregation due to Surface Nanobubble Interactions During the Onset of Thermal Burn Injury" (2016). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 2862.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/2862