Type
Text
Type
Thesis
Advisor
Qin, Yi-Xian | Bluestein, Danny | Lieber, Barry Baruch
Date
2012-05-01
Keywords
Collagen Fiber Angle, coronary vulnerable plaque, fluid-structure interaction, IVUS, Microcalcification, micro-CT | Biomechanics
Department
Department of Biomedical Engineering
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/70782
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
Fluid-structure interaction (FSI) simulations were conducted in patient-specific coronary vulnerable plaque (VP) geometries reconstructed from Micro-CT and intravascular ultrasound (IVUS), in order to study the effects of several biomechanical factors on plaque vulnerability. The models reconstructed from IVUS included vessel wall, fibrous cap, lipid core and large calcifications. A model reconstructed post mortem from a coronary specimen of a patient with confirmed VP was scanned using high resolution micro-CT. This enabled capture of micro calcifications embedded in the VP fibrous cap in addition to the plaque components mentioned above. Regions susceptible to tissue failure were studied. The thin fibrous cap regions of the plaque were characterized by high stress concentrations. The presence of single or multiple micro-calcified spots embedded within the fibrous cap was studied as well. Micro-Ca significantly enhanced stresses within the fibrous cap, significantly contributing to the risk of rupture. Micro-Ca embedded in the fibrous cap produced increased stresses predicted by previously published analytical model, and corroborated our previous studies. The `micro-CT to FSI' methodology may offer better diagnostic tools for clinicians, while reducing morbidity and mortality rates for patients with vulnerable plaques and ameliorating the ensuing healthcare costs. Similarly, Fluid-Structure-Interaction (FSI) simulations of three-dimensional patient-based geometries of coronary arteries reconstructed based on Intravascular Ultrasound (IVUS) imaging dataset were performed to elucidate the correlation and dependence of crucial biomechanical risk factors, such as the fibrous cap thickness, hypertension, presence of microcalcification (micro-Ca) in the fibrous cap, and arterial anisotropy, in stress/strain distributions. It was verified that von Mises stress would exponentially increase with a fibrous cap thinner than 65 . On average, von Mises stresses increased by 32%, 34%, 30%, and 34% following a 25% simulated blood pressure elevation in the four cases studied. Stress-driven reorientation and biochemically degradation of the collagen fibers in the vessel due to atherosclerosis would potentially result in an anisotropic fibrous cap with 65?? degree fiber angles. Compared to its isotropic counterpart, a 23% von Mises stress increase was observed when the fibrous cap containing a micro-Ca was modeled as anisotropic material. IVUS based patient specific FSI simulations mapping the wall stresses and analyzing the biomechanical risk factors can be used as an additional tool for clinicians to determine proper treatment and intervention. | 96 pages
Recommended Citation
Liang, Xuan, "Vulnerable Plaque Risk of Rupture Examined via Patient Based Micro-CT and IVUS Fluid-Structure Interaction Studies" (2012). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 2.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/2