Type
Text
Type
Dissertation
Advisor
Jacobsen, Chris J. | Alexandre G. Abanov | Anand Sivaramakrishnan | Hanfei Yan.
Date
2010-08-01
Keywords
Biophysics, General Physics, Optics -- Physics, Radiation | Coherent diffractive imaging, X-ray diffraction microscopy
Department
Department of Physics
Language
en_US
Source
This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree.
Identifier
http://hdl.handle.net/11401/72677
Publisher
The Graduate School, Stony Brook University: Stony Brook, NY.
Format
application/pdf
Abstract
X-ray Diffraction Microscopy (XDM) has been gaining in popularity for nanoscale imaging of biological and material science samples. Its high penetration depth (compared to electron microscopy) and its good dose efficiency (compared to its lens-based X-ray alternative) make it uniquely suited for imaging whole biological specimens, where radiation damage is a concern. Despite these advantages, XDM is still far from being a routine imaging tool. This is due to the computational challenge of reconstructing an image from recorded diffraction intensities as well as difficult-to-satisfy experimental requirements. I address these challenges by improving on the computational methods and by implementing a more reliable experimental geometry for our existing diffraction microscope at the Advanced Light Source, Lawrence Berkeley Lab. First, a software library has been developed that streamlines the post-experiment processing of data and that improves on an important aspect of data analysis. Results will be shown that illustrate the collective improvement to the reconstruction process. A modified version of a tool commonly used to assess the consistency of reconstructions is proposed and criteria of its validity are derived. Results show that it has improved utility for judging reconstruction quality. Second, a scanning-type experimental setup has been implemented for our existing diffraction microscope. Several possible geometries are discussed and preliminary results from recent experimental data are shown.
Recommended Citation
Steinbrener, Jan Felix, "X-ray Diffraction Microscopy: Computational Methods and Scanning-type Experiments" (2010). Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions). 1880.
https://commons.library.stonybrook.edu/stony-brook-theses-and-dissertations-collection/1880